A Prospective study to compare T2 Weighted MRI to CT imaging in volume delineation for radiotherapy planning in carcinoma cervix

OBJECTIVES: To compare magnetic resonance imaging (MRI), computed tomography (CT), and clinical examination to evaluate the impact of MRI on target volume delineation as compared to the volumes obtained on a CT scan and also to see the effect on staging and prognosis. METHODS: Twenty patients diagnosed with locally advanced carcinoma cervix underwent planning CT abdomen and pelvis which was fused with T2 weighted MRI images to evaluate the impact of MRI on target volume delineaton , to see if CT scan along with clinical findings can be a good alternate to MRI scan.A descriptive analysis and frequency distribution of the patient characteristics was done. Fisher's exact test was done to find out relationship between prognostic factors and image findings. PABAK was done to compare different imaging modalities (CT versus MRI).Paired T test was used for tumor volume comparison. RESULTS: MRI was better in tumor delineation as compared to CT scan. Additional imaging gave information regarding local extent of the disease, nodal involvement . Upstaging of disease helped in selecting appropriate treatment modality. CONCLUSION: Though the findings on CT, MRI, or PET examinations are not mandatory for FIGO staging it could be of additional benefit and provide extra information that would result in stage migration, help appropriate selection of treatment modality,result in more accurate radiotherapy treatment planning and also provide prognostic information that would impact on the outcome of treatment and survival. CT with good clinical examination could be used as an alternate to MRI where MRI is not feasible

Pedestrian Flow Characteristics at Upstream and Downstream of Bottleneck for Unidirectional Flow under Normal Conditions

The study of pedestrian flow characteristics at upstream and downstream of bottlenecks is important from level of service and evacuation perspective. Many controlled laboratory experiments have been conducted to study pedestrians’ behavior at bottlenecks. However, it is unclear whether experiments can reproduce real crowd flow characteristics. In this paper, real field data was collected at normal conditions for unidirectional pedestrian movement at Mahakaleshwar, a Hindu temple at Ujjain, India during Mahashivaratri, a festival day on which a large number of pilgrims visited the temple. Along the corridor there is a width reduction at a U-turn which creates a bottleneck. It is necessary to study pedestrian flow characteristics at bottlenecks to ensure desired level of service at temple premises during heavy flow. The speed-density relationships of upstream and downstream sections were compared and it was found that flow behavior at both the sections of bottleneck severely differ from each other. Pedestrians in the upstream are either at free flow speed for very low density values or moving slowly for intermediate to high range of density values. From the speed-density relationship, it can be concluded that pedestrians at upstream had visual clues of congestion ahead at bottleneck (pedestrian could also see the downstream flow through barricades). Therefore, pedestrians wait at their position, stay in their comfort zone and do not push each other. Thus, even at intermediate local density, pedestrians have such low speeds. This violates the general assumption that pedestrians change their speed only at the shockwave boundary. The movement of pedestrians at upstream is governed by local density and information of congestion status ahead, whereas pedestrian movement at downstream is governed by factors like density, side friction and pedestrians’ willingness to compensate for the delay at bottleneck. This study is expected to have application in planning and operation of pedestrian facilities

Determination of pedestrian’s personal space in mass religious gatherings - A case study of Kumbh Mela

Personal space can be defined as the physical distance between two individuals in a social environment. It varies from person to person depending on culture and context and there are significant individual differences too. Studying personal space includes the ability to recognize the various zones of involvement and the activities, relationships, and emotions associated with each zone. This paper tries to formulate and define personal space in high density crowd situations in Kumbh Mela, one of the world’s largest mass religious gatherings. Video data of pilgrims taking part in the Panchkroshi Yatra, a religious walkathon which is a part of KumbhMela, is used for the analysis of factors affecting personal space. To identify the thresholds of personal space, walking speed of individuals, gender, presence of luggage and the number of males and females surrounding an individual have been considered. It is found that the average speed of the individual, the group size,and the gender ratio of group members have a significant effect on the personal space of an individual. Also, it is observed that the personal space follows an asymmetrical pattern rather than a symmetrical pattern

Study the effect of intermediate and closer stiffener on the behaviour of the cold - formed steel lipped channel section under axial compression

Cold-Formed steel built-up columns are commonly used as compression member in the industrial roof and long span bridge structures to carry larger load. To improve the strength and stiffness of the cold-formed section, the built-up column with additional stiffeners and lacings are used. This paper reports the results of experimental tests conducted on built-up cold-formed columns, composed with the combination of intermediate and closer stiffeners with pin-ended condition under axial compression. Totally twelve columns with or without intermediate and closer stiffeners were tested to failure. The experimental results aim to quantify the effect of cross-section, intermediate and closer stiffener on the overall performance, including strength, strain and failure modes for the built-up column. The Finite element model was developed by ANSYS software and the model is validated with the experimental results. The built-up column strength predicated by recommended design equations of American Iron and Steel Institute (AISI) exhibited good agreement with the ultimate load of built-up columns obtained both by experimental and numerical. Based on this study a recommendation is proposed to DSM for the CFS built -up columns with intermediate and closer stiffeners

Study the effect of intermediate and closer stiffener on the behaviour of the cold - formed steel lipped channel section under axial compression

Cold-Formed steel built-up columns are commonly used as compression member in the industrial roof and long span bridge structures to carry larger load. To improve the strength and stiffness of the cold-formed section, the built-up column with additional stiffeners and lacings are used. This paper reports the results of experimental tests conducted on built-up cold-formed columns, composed with the combination of intermediate and closer stiffeners with pin-ended condition under axial compression. Totally twelve columns with or without intermediate and closer stiffeners were tested to failure. The experimental results aim to quantify the effect of cross-section, intermediate and closer stiffener on the overall performance, including strength, strain and failure modes for the built-up column. The Finite element model was developed by ANSYS software and the model is validated with the experimental results. The built-up column strength predicated by recommended design equations of American Iron and Steel Institute (AISI) exhibited good agreement with the ultimate load of built-up columns obtained both by experimental and numerical. Based on this study a recommendation is proposed to DSM for the CFS built -up columns with intermediate and closer stiffeners

Theoretical prediction and experimental study of a ferromagnetic shape memory alloy: Ga_2MnNi

We predict the existence of a new ferromagnetic shape memory alloy Ga_2MnNi using density functional theory. The martensitic start temperature (T_M) is found to be approximately proportional to the stabilization energy of the martensitic phase (deltaE_tot) for different shape memory alloys. Experimental studies performed to verify the theoretical results show that Ga_2MnNi is ferromagnetic at room temperature and the T_M and T_C are 780K and 330K, respectively. Both from theory and experiment, the martensitic transition is found to be volume conserving that is indicative of shape memory behavior.Comment: 11 pages, 3 figure

SPECTRO-ANALYTICAL, COMPUTATIONAL AND BIOLOGICAL STUDIES ON 4-PYRIDINE CARBOXALDEHYDE-3-HYDROXY-5-(HYDROXY METHYL)-2-METHYL HYDRAZONE HYDROCHLORIDE AND ITS CU (II) COMPLEXCA

Objective: The title compound 4-pyridine carboxaldehyde 3-hydroxy-5-(hydroxy methyl)-2-methyl hydrazone (PCHHMMH) hydrochloride an analogue of Pyridoxal isonicotinoyl hydrazone PIH, is an iron chelator. The PCHHMMH has potential donor sites suitable for metal ion binding, the study on structural aspects of the compound and its copper complex are explored. With a view to understand biological importance of title compounds, antimicrobial and cytotoxic studies were planned. Methods: In the present study the spectroanalytical techniques employed were pH-metry, spectrophotometry, IR, 1H & 13C-NMR, UV-Vis, ESR, Magnetic measurements, TGA and SEM. The computational method employed is HyperChem 7.5 software. The antimicrobial studies were carried out by agar disc diffusion method for antibacterial studies against Gram positive and Gram negative bacteria. The cytotoxic potential was measured by Sulforhodamine B (SRB) method against selected tumor cells. Results: The equilibrium studies by employing pH-metric method inferred the dissociation of two protons in it. Further titration in presence of Cu (II) ion, it is confirmed the release of two protons from title compound and formation of corresponding complex. The orientations of frontier orbitals for molecular and ionized forms of compound were computed to understand the electronic properties. The Cu (II) PCHHMMH complex was characterized by spectroanalytical methods and screened for, antimicrobial and cytotoxic activities. Conclusion: As the structural features are important to understand the chemical behavior of metal complexes, in the present study copper complex was synthesized and characterized by employing various spectro-analytical tools viz; IR, 1H & 13C-NMR, UV-Vis, ESR, Magnetic measurements, TGA and SEM. Further the antimicrobial and cytotoxic activities were evaluated and correlated with computed QSAR data

Isomerism in flowers of Azanza Lampas Dalz ( Malvaceae)

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A note on the cytology of Hibiscus Punctatus Dalz, (Malvaceae)

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